Optimal lead follicle size for human chorionic gonadotropin trigger in clomiphene citrate and intrauterine insemination cycles: an analysis of 1,676 treatment cycles

ObjectiveTo identify the optimal lead follicle size for hCG trigger in clomiphene citrate (CC)–intrauterine insemination (IUI) cycles.DesignRetrospective cohort study.SettingUniversity-affiliated center.Patient(s)Patients <40 years of age with ovulatory dysfunction or unexplained infertility undergoing their first CC-IUI cycle.Intervention(s)Ovulation induction, trigger, and IUI.Main Outcome Measure(s)Clinical pregnancy rate (CPR) was primary outcome plotted against increments 1 mm. Odds ratios 95% confidence intervals associations between CPR were calculated from a multivariable logistic regression model. A receiver operating characteristic (ROC) curve generated as function size.Result(s)1,676 cycles included. The overall 13.8% (232/1,676). There no difference baseline demographics ovulation induction parameters patients who did not conceive. odds clinical 2.3 2.2 times higher sizes 21.1–22.0 mm >22.0 mm, respectively, compared referent category 19.1–20.0 Lead an independent predictor CPR, even after accounting confounders. 22.1 corresponded to sensitivity specificity 80.1% 90.4% pregnancy, area under ROC 0.89.Conclusion(s)hCG administration at is associated infertility. To cycles. Retrospective study. University-affiliated center. Patients cycle. Ovulation IUI. Clinical size. 1,676 0.89.